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DTSTART;TZID="Pacific Time (US & Canada)":20210223T123000
DTEND;TZID="Pacific Time (US & Canada)":20210223T133000
SUMMARY:Oral Prelim Exam Announcement – Department of Chemistry
LOCATION:Online
DESCRIPTION:Title: Development of a Universal Drug-Linker Platform for Targeted Drug Therapy\n\nHosog Yoon (Berkman Group)\n\nAbstract: Targeted drug therapy is a promising approach to selectively treat cancerous tissues, however further development is needed in the field of acid-labile linkers. Cleavable linkers are fundamental for efficient delivery of cytotoxic drugs, but are also the key factor in determining the toxicity of drug conjugates in targeted drug therapy. One of the biggest challenge in this field is the availability of a versatile, acid-labile linker. Recently in the Berkman group, we developed an acid-labile phosphoramidate (PhosAm) cleavable linker that exhibits stability at physiological conditions, but predictable cargo-release at endosomal/lysosomal pH. In addition, we have shown that by outfitting this PhosAm linker with self-immolative spacers, it can be coupled to both alcohol and amino groups, thus allowing it to accommodate various drug payloads and marking it as a much-needed versatile platform for targeted drug therapy. In this work, our goal is to develop and optimize an effective drug-linker platform to overcome current limitations of acid-labile linkers in targeted drug therapy. The modular approach for theses platforms allows for the introduction of an azide functionality to accommodate click-chemistry for conjugation to antibodies or small-molecule inhibitors to deliver the relevant therapeutic agent selectively to the desired cell.\n\nZoom info:\n\nImportant Note: Both internal and external WSU meeting attendees must be signed into Zoom to join the meeting.\n\nPlease refer to this guide on Joining WSU Zoom Meetings before trying to join the meeting:\n\nhttps://confluence.esg.wsu.edu/display/KB/Zoom+-+Joining+Meetings+and+Best+Practices\n\nJoin from PC, Mac, Linux, iOS, or Android: https://wsu.zoom.us/j/99642864574 \n\nMeeting ID: 996 4286 4574\n\nDate & Time: Feb 23, 2021 12:30 PM Pacific Time (US and Canada)\n\nJoin from WSU Conference Room System (Polycom)\n\n1.      Using the touch panel, or\n\n2.      : 162.255.37.11\n\n    3. Press the pound key twice '##'\n\n    4. Enter the Meeting ID: 996 4286 4574\n\n    5. Press 'Call'\n\nJoin from Conference Room System with SIP\n\n                99642864574@zoomcrc.com\n\n Share Screen/Content Wirelessly\n\n                Go to https://share.zoom.us and enter Meeting ID: 996 4286 4574             \n\nPhone Call (long distance)\n\n                +1 253 215 8782\n\n                +12532158782,,99642864574# US (One Tap Mobile Call)\n\nFind your international phone number: https://wsu.zoom.us/u/afiFms167\n\nFor technical support with WSU conference rooms, contact your local IT team\n\nFor support or feature requests, please go to https://its.wsu.edu/wsu-video-conferencing-services/\n\n 
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