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DTSTART;TZID="Pacific Time (US & Canada)":20220426T123000
DTEND;TZID="Pacific Time (US & Canada)":20220426T133000
SUMMARY:Organic Chemistry Seminar – Esther Dodson, Chemistry PhD Student
LOCATION:Fulmer Hall
DESCRIPTION:Title: A ratiometric near-IR fluorescent BODIPY probe for in vivo tracking of β-galactosidase activity\n\nAbstract: β-Galactosidase (β-Gal) is an important biomarker for metastatic ovarian cancers, with β-Gal being overexpressed in cancer cells compared to healthy ovarian tissue. Fluorescent imaging of in vivo β-Gal activity has become an accepted method for diagnostic screening and evaluation of cancers. Several fluorescent probes have previously been reported for tracking β-Gal, however these probes suffer from limited tissue penetration due to their short-wavelength fluorescence and from imprecise quantification due to their ON/OFF sensing design. The fluorescent 1,3-dimethyl-BODIPY scaffold can be readily functionalized in order to create new tunable near-IR fluorescent reporters. The BODIPY-βgal probe presented herein allows for near-IR, dual-channel ratiometric tracking of β-Gal activity, as well as real-time in vivo visualization of β-Gal activity in mice models.
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TRIGGER;RELATED=START:-PT00H15M00S
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