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Thursday, November 9 @3:30 pm
Mathematics and Statistics Colloquium: Dr. Joshua Schiffer
Online - Spark

Our group has developed mathematical models to define variable SARS-CoV-2 shedding kinetics observed in the general population. We leveraged this model to accurately simulate clinical trials. Our models help identify why nirmatrelvir / ritonavir was extremely effective as an early therapy but failed a post exposure prophylaxis, and why viral rebound is common on this drug. We also explore mechanisms for nirmatrelvir / ritonavir’s superiority relative to molnupiravir.