Chemistry

Some observations on the role of solvent in the self-assembly

Speaker: Prof. Brian A. Powell, Fjeld Professor in Nuclear Environmental Engineering and Science, Clemson University

Title: Understanding tetravalent actinide oxide formation, stability, and dissolution under far field environmental conditions

Abstract: Comprehensive thermodynamic understanding of nuclear materials is paramount for long-term management of legacy nuclear waste and commercial spent nuclear fuel. …

Speaker: Peter Jensen, chemistry graduate student

Group: Guo/Moreau

Title: Structure and Thermal Properties of Lanthanide Doped UO2

Abstract: Fission reactions in UO2 generate rich chemistry and complex structures within its fluorite matrix. Lanthanides (Ln), as one of the dominating fission products, are able to be incorporated into the UO2 structure,…

Speaker: Prof. Takashi Tsukamoto, Medicinal Chemistry, Johns Hopkins Drug Discovery Program, Associate Professor of Neurology, Johns Hopkins University
Title: Discovery of ASTX727 (INQOVI®), an oral combination of decitabine and cedazuridine for the treatment of myelodysplastic syndromes

Title: Leveraging chemometrics of optical spectroscopy in challenging systems

Speaker: Emily Hicks, chemistry graduate student
Title: In Situ Imaging and Computational Modeling Reveal that Thiophene Complexation with Cobalt Octaethylporphyrin and Graphite is Highly Cooperative

Adjuvant additives significantly increase vaccine efficacy. However, adjuvants also cause inflammatory side-effects, such as pyrexia, which currently limits their use. To address this, we created a thermophobic vaccine adjuvant engineered to attenuate potency at temperatures correlating to pyrexia. Thermophobic adjuvants were synthesized by combining a rationally designed trehalose glycolipid CLR agonist with thermoresponsive poly-N-isoporpylacrylamide (NIPAM) via Reversible Addition-Fragmentation Chain-Transfer polymerization.