March 2022
As global energy demands increase, new forms of energy storage are required for both short- and long-term storage applications. Electrochemical energy storage systems (i.e. batteries, fuel cells, and supercapacitors) are of great appeal for versatility and ease of use.
Aquaporin-4 (AQP4) is an integral water channel protein located in the plasma membrane of astrocyte cells in the central nervous system (CNS) and helps to regulate water-ion homeostasis. Some isoforms of AQP4 further order themselves into aggregates known as orthogonal arrays of particles (OAPs).
Self-assembled molecular systems hold great promise for programmed surface functionality. There has been significant development in recent years in using redox-active organic ligands to coordinatesingle transition metal centers in patterned arrays at surfaces.
Thiols play critical roles in cell biology. These include maintaining redox homeostasis, as well as the modulation and regulation of protein activity. Dysregulation of thiols has been linked to several diseases including diabetes, cancer, and neurodegenerative disease. For this reason, there is a need for tools for the detection and labeling of thiols. Thiol blocking reagents can be used to label and identification of protein thiols.
Title: Module Smart Molecules for PSMA-Targeted Chemotherapy
Abstract: Prostate cancer is a dynamic and heterogeneous disease, necessitating a diverse arsenal of targeted chemotherapeutic agents for treatment. The cell-surface enzyme prostate-specific membrane antigen (PSMA) is a hallmark biomarker for targeted therapy and imaging of prostate cancer. While considerable efforts and…
Title: Examining the Lewis Acid-Base Interactions Between Uranyl Complexes and Various Lewis Acids
Abstract: The reactivity of the uranyl cation ([UO2]2+) is an underdeveloped area of uranium chemistry due to the high stability of the U=O bond, which is resistant to ligand exchange or cleavage. Current research has focused on…
Auxiliary field quantum Monte Carlo (AFQMC) is a stochastic method which offers great potential to solve persisting issues in thermochemical calculations of actinides.
The protein machinery for biological conversion of sunlight into chemical energy is harbored in one of nature’s most sophisticated membrane system, the thylakoid membrane inside plant chloroplasts.
Esters are an extremely important class of compounds due to their extensive use. The decomposition of esters through hydrolysis is an extremely slow kinetic process and requires extreme conditions to proceed at a reasonable rate. One catalyst system that shows promise of being able to catalyze this process are Ru complexes bearing tridente-bisphosphinoamino pincer ligands.
Machine learning (ML) is quickly becoming a premier tool for modeling chemical processes and materials. Generally, ML provides a surrogate model trained on the dataset of some reference data. This model establishes a relationship between structure and underlying chemical properties, guiding chemical discovery.