Chemistry

Research focus is on design of synthetic high density lipoprotein (HDL) nanoparticles for treatment of cardiovascular disease. We discover novel ApoA-I mimetic peptides, explore biophysics of peptide-lipid interactions and optimize HDL compositions for interaction with specific cellular receptors, transporters and enzymes involved in RCT. We examine sHDL biodistribution, pharmacokinetics and pharmacodynamic properties.

Multidrug Resistant (MDR) cancers attenuate chemotherapeutic efficacy through drug efflux via ABC (ATP-Binding Cassette) transporters, including P-glycoprotein 1 (P-gp or ABCB1/MDR1). Conversely, Toll-Like Receptor (TLR) agonist immunotherapies modulate activity of tumor-infiltrating immune cells in local proximity to cancer cells and could benefit from the enhanced drug efflux in MDR cancers. However, the effect of acquired drug resistance on TLR agonist efflux is largely unknown.

Speaker: Jiahong Li
Group: Qiang Zhang
Title: Carboxylate-based Metal–organic frameworks: Synthesis, Thermodynamic Analysis, and Catalytic Activity

Speaker: Jessica Carder, chemistry graduate student
Group: Jim Brozik
Title: S-Palmitoylation Dependent Self-Assembly and Thermodynamics of Human Aquaporin-4 M1 in Biomimetic Membranes

Speaker: Nitesh Kumar
Group: Aurora Clark
Title: Chemical and Transport Phenomena at Biphasic Interfaces

Speaker: Prof. H. Peter Lu, Bowling Green State University, Department of Chemistry, Center for Photochemical Sciences
Title: Single-Molecule Spectroscopy and Force Manipulation Studies of Protein Dynamics and Signaling

Title: Ab initio Calculations Targeting Chemically Accurate Thermochemical Properties of Actinide Molecules

Title: Development of a ratiometric fluorescence probe for real-time tracking of PSMA-targeted drug delivery

Title: Thermodynamics of Layered Double Hydroxides for Removal of Iodine Species from Aqueous Media

Title: 3D Printing Technology in Low-cost Diagnostic Sensors for Neurological Disorder

Speaker: Prof. Anjali Sharma, Washington State University, Department of Chemistry

Title: Novel Dendritic Nanostructures for Cell-Targeted Drug Delivery

Abstract: Poor transport of therapeutics across various physiological barriers limits the development of effective treatments for central nervous system (CNS) disorders, cancer and beyond. The primary clinical challenge in…