Chemistry

The ability to rapidly distinguish between individual structures in dilute mixtures of complex isomers remains a bottleneck in analytical chemistry. One field in analytical chemistry that shows great promise in distinguishing between isomers is ion mobility spectrometry (IMS).

The goal of the project was to synthesize asparagine-linked glycoproteins with a natural linkage. We described an aspartyl thioester unnatural amino acid and its incorporation into a recombinant protein.