CHE 598 Seminar: Additive Manufacturing Of Biomaterials In Bone Tissue Engineering And Drug Delivery
About the event
SPEAKER: Dr. Susmita Bose, Westinghouse Distinguished Professor, School of Mechanical and Materials Engineering, WSU
BIOGRAPHY:
Susmita Bose is a Westinghouse Distinguished Professor at the School of Mechanical and Materials Engineering, an affiliate faculty of the Department of Chemistry, and Elson Floyd College of Medicine at Washington State University. Prof. Bose’s interdisciplinary research interest lies at the interface of Chemistry, Materials Science, Mechanical Engineering, Bioengineering, and Biology, focusing on 3D-printed bone scaffolds, implant materials, and drug delivery vehicles. Prof. Bose received the NSF CAREER and the prestigious Presidential Early Career Award for Scientists and Engineers (PECASE) awards. She has advised over 45 graduate students for their MS and PhD, and over 40 undergraduate students in research, and published over 325 technical articles, including over 280 journal articles, 24 book chapters, 9 edited books, and 13 issued patents. Her research papers have been cited ~36,500 times, “h” index of 97 (Google Scholar, 08/2024). She is a fellow of the American Association for the Advancement of Science (AAAS), the National Academy of Inventors (NAI), the Materials Research Society (MRS), ASM International, the American Institute for Medical and Biological Engineering (AIMBE), the American Ceramic Society (ACerS) and the Royal Society of Chemistry (RSC). She received the PACE and Fulrath Awards from the American Ceramic Society. The Washington Biotechnology and Biomedical Association named Prof. Bose Life Science Innovation, Northwest Women to Watch Honoree. She received the International Society for Ceramics in Medicine research excellence award. In 2017, she was elected as a member of the Washington State Academy of Sciences (WSAS) and last year as a Board of Director member of the WSAS. She received the WSU Distinguished Faculty Award and the WSU Sahlin Faculty Excellence Award for research scholarships and art. Since 2011, Dr. Bose’s group research on 3D printed ceramic bone scaffolds with controlled chemistry for bone tissue engineering and natural medicinal compounds has been featured by the AP, BBC, NPR, CBS News, MSNBC, ABC News, and many other TV, radio stations, magazines and news sites all over the world, including R&D magazine, Science Daily News, etc. Other interests: Learning about natural medicinal compounds and Indian Classical music/Noble Laureate Tagore songs.
ABSTRACT:
3D printing (3DP) or additive manufacturing (AM) is becoming essential in patient-matched implants due to shorter manufacturing lead time and special anatomical needs or concerns related to specific defect size complexity. Additively manufactured components must be controlled and optimized carefully for reproducibility, machine-to-machine part quality variations, and process-specific material properties. Establishing process property relationships for different AM techniques is vital to successfully implementing these manufacturing practices in biomedical devices. Complex biomaterials, e.g., calcium phosphate (CaP) ceramics compositionally similar to the inorganic part of the bone, show significant promise toward implant applications in both 3DP tissue engineering scaffolds and surface-modified load-bearing implants, such as hip and knee implants. We have used our lab-built extrusion-based and commercial binder jetting 3DP machines for the past 15 years to critically identify and understand the effects of process-property variations on 3DP CaP bioceramic scaffolds, with an average pore size of 250-500 microns, 30 to 50 volume % porosity and compressive mechanical strength of >15 MPa, followed by natural medicinal compounds (NMCs) loading on those CaP scaffolds. We have also designed and built a 3DP machine that prints high-viscosity slurry to directly print doped CaP–polymer scaffolds with a similar inorganic composition as bone. In vivo studies show improved osteogenesis, angiogenesis, and controlled drug delivery using NMCs in these 3DP scaffolds and coatings. 3D interconnected channels in CaP scaffolds provide pathways for micronutrients, improved cell-material interactions, and increased surface area, allowing improved mechanical interlocking between scaffolds and surrounding bone. These systems show promise for use in orthopedic and dental devices while eliminating the need for autografts and the second site surgery for harvesting and improving current hip/knee implant lifetime. The presentation will address the design of next-generation bone tissue engineering scaffolds, hip/knee devices, and NMC delivery based on clinical needs in the fixation of bone disorders.