About the event
Speaker: Anubhav Dhull, chemistry graduate student
Title: Dendrimers: From Design, Synthesis to their Biomedical Applications
Abstract: Dendrimers are a unique class polymeric nanomaterials that have shown remarkable potential in various applications including catalysis, energy, sensing, and drug and gene delivery. This is mainly due to their tunable chemistry and physicochemical properties such as mono-dispersity, 3-D hyper hyperbranched structure with internal cavities, and controlled architecture which provide them an edge over other polymeric systems. Due to their highly controlled architecture and a low poly-dispersity index, dendrimers can be precisely designed to have desirable pharmacokinetic and pharmacodynamic properties for targeted and controlled drug delivery applications. Therapeutic payloads can be physically encapsulated within the core of the dendrimers or covalently conjugated on their periphery along with targeting ligands and other bioactive molecules. The traditional classical synthetic protocols used for the construction of dendrimers had several limitations associated with their easy reproducibility, defect-free structure, and scalability limiting their use for medical applications. Several accelerated approaches have been developed in the past few decades to overcome these issues. In this talk, I will present various methodologies for dendrimer synthesis, along with their applications in the fields of biomedicine and nanotechnology.