About the event
Presenter: Dr. Arden Perkins: Institute of Molecular Biology at the University of Oregon
Host: Chulhee Kang
Abstract: Sulfur oxidation chemistry is an ancient mechanism by which cells mediate redox stress. Sulfur oxidation plays important roles in bacterial diseases, where immune cells strive to kill invading bacteria through the production of reactive oxygen and nitrogen species and bacteria sense and eliminate these toxins through proteins with sulfur oxidation-based mechanisms. My talk will examine the structural basis for these reactions, the surprising finding that some bacterial pathogens are attracted to bleach (HOCl), and the possibility of targeting these bacterial proteins with novel antibiotics.
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Meeting ID: 921 8127 5163
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