Chemistry Proposal Defense – Anubhav Dhull

About the event

Speaker: Anubhav Dhull

Group: Dr. Anjali Sharma

Title: Dendrimer Based Targeted Nanotherapies for the Treatment of Brain and Ocular Disorders and Cancer

Abstract: Dendrimers are a unique class of polymeric nanomaterials that have demonstrated significant potential in areas such as catalysis, energy, sensing, diagnostics, and drug and gene delivery. This versatility in their applications is primarily due to their tunable chemistry and distinctive physicochemical properties, including monodispersity, a 3-D hyperbranched structure with internal cavities, and control over size, shape, peripheral groups. All these properties offer advantages over other polymeric systems. With their highly controlled architecture and low polydispersity index, dendrimers can be precisely engineered to achieve favorable pharmacokinetic and pharmacodynamic profiles, making them well-suited for targeted and controlled drug delivery applications. However, only a few dendrimer-based drug delivery systems have reached the market. This is largely due to limitations in traditional synthetic methods, which lead to challenges in reproducibility, defect-free construction, and scalability, thereby hindering commercialization and clinical translation. This proposal will outline innovative strategies in dendrimer synthesis aimed at overcoming these challenges by adopting simplified designs, incorporating biocompatible and non-toxic components, using cost-effective starting materials, and employing highly efficient, scalable chemical processes. The main focus will be on the design, synthesis, and characterization of various dendrimer-based nanosystems for targeted delivery of therapeutics for the treatment of central nervous system diseases and cancer.